At the beginning of the game, Link goes to the Sanctuary to return the Captain of the Guards' sword to him, and meets Seres outside. She informs Link that the Captain is inside, talking with her father, and goes to fetch him, but the door is slammed shut and she is heard screaming. Link enters through a hidden passageway, but is too late to stop an intruder named Yuga from transforming Seres into a painting and kidnapping her.
It is later revealed that Seres is one of the Seven Sages, descended from the original group of Seven Wise Men who sealed Ganon away. When Link finally catches up with Yuga shortly after arriving in Lorule, the evil wizard uses the paintings of the Seven Sages to revive Ganon, and absorbs his power. The paintings are then spread throughout Lorule, with Seres's being taken to the Skull Woods. It is eventually found by Link, who returns Seres to normal. Grateful, Seres thanks Link for saving her and wishes him good luck on his adventures. After Link frees all sages, Seres uses her power alongside them to grant the Triforce of Courage to the young hero.
As part of the A Link Between Worlds DLC, Seres' painting Portrait can be seen in Yuga's Victory Cutscene along with the paintings of the other Seven Sages.