The Sanctum is a location from The Legend of Zelda: Breath of the Wild. It is located inside the Hyrule Castle, in the Central Tower region. The Sanctum is the room where Link confronts Calamity Ganon. If he hasn't retaken all Divine Beasts, he will have to battle Windblight Ganon, Fireblight Ganon, Waterblight Ganon, and Thunderblight Ganon there.