When Link returns from Tail Cave after having retrieved the Full Moon Cello, he is approached by the Quadruplets and told that the King Moblin and his Moblin underlings have kidnapped Madam MeowMeow's biggest Bow-Wow. She asks Link to chase down the Moblin gang and rescue her pet. Link eventually finds the Moblin Cave and defeats the enemies within it. He is eventually confronted by the King Moblin, who refuses to return the Bow-Wow. He battles Link but is defeated. Link releases the Bow-Wow from the rock to which it had been chained and takes the pet back to Mabe Village.
Madam MeowMeow is overjoyed to see her pet again and gives Link a healing kiss for his efforts. She also allows him to keep the Bow-Bow for a little while. This proves to be useful, as the Bow-Wow promptly devours the Goponga Flowers that infest the Goponga Swamp when they enter the area. With the Goponga Flowers that once blocked Bottle Grotto now gone, Link is free to enter the dungeon and retrieve the Conch Horn. When he exits the dungeon, Bow-Wow has returned to Madam MeowMeow on its own accord.